Where less may be more: how the rare biosphere pulls ecosystems strings

Metronomic Chemotherapy: When Less May Be More

The use of low dose continuous schedules of chemotherapy (i.e. metronomic chemotherapy), delivered at lower doses by necessity compared to traditional dosing schemes, has become an increasingly popular addition to patient management in veterinary medical oncology. While the concept itself is not new, as low dose, maintenance chemotherapy protocols have been important components of treatment for...

High-Dose Antiangiogenic Therapy for Glioblastoma: Less May Be More?

John F. de Groot Author’s Affiliations: Brain Tumor Center and Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX Running Title: Dosing effects of antiangiogenic therapy in glioblastoma

High-dose antiangiogenic therapy for glioblastoma: less may be more?

Targeting angiogenesis in glioblastoma rapidly reduces vascular permeability and contrast enhancement on MRI and prolongs progression-free survival. The long-term efficacy of bevacizumab and other antiangiogenic agents is limited, however, because of the rapid development of resistance. Alternative dosing approaches may be one mechanism of prolonging therapeutic efficacy.

Irreducibility to the One-More Evaluation Problems: More May Be Less

For a random-self-reducible function, the evaluation problem is irreducible to the one-moreevaluation problem, in the following sense. An irreduction algorithm exists that, given a re-duction algorithm from the evaluation to the one-more evaluation problem, solves a separatorproblem: the evaluation problem itself. Another irreduction shows that if the computationalDiffie-Hellman...

Ablation of Atrial Fibrillation: How Can Less Be More?